Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HK1 | P19367 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24538298 | 0.75 | GABRA1 (0.35) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL16259907 | 0.71 | SMN1; SMN2 (0.37) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL12602353 | 0.70 | PDK2 (0.31) | — | |
| SCHEMBL2091242 | 0.70 | LMNA (0.47) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL5843250 | 0.70 | ALDH1A1 (0.43) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL29892233 | 0.70 | ALDH1A1 (0.43) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL30124712 | 0.69 | POLB (0.45) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL1886976 | 0.69 | POLB (0.45) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL26617136 | 0.67 | ALDH1A1 (0.41) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA | |
| SCHEMBL26608375 | 0.67 | ALDH1A1 (0.41) | ALDH1A1MAPK1SMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364313-B1 | AZA-BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-01-08 | — | — | EP | disclosed |