Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.44 |
| ▸ | MAOB | P27338 | 7/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TGM2 | P21980 | 5/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14217669 | 0.74 | GABRA1 (0.60) | LMNAHPGD | |
| SCHEMBL12685491 | 0.74 | RAB9A (0.47) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL21312677 | 0.73 | EGFR (0.59) | TNKSRAB9ACES1NPC1ALDH1A1 | |
| SCHEMBL12204565 | 0.73 | SMN1; SMN2 (0.62) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL822777 | 0.72 | SMN1; SMN2 (0.44) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL12204569 | 0.71 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL16230166 | 0.70 | TNKS (0.37) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL17355202 | 0.70 | TNKS (0.37) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL13589297 | 0.70 | SMN1; SMN2 (0.52) | TNKSRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL172700 | 0.69 | ALDH1A1 (0.56) | TNKSRAB9ASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2682393-A1 | Inhibitors of HCV NS5A comprising a bicyclic core. | Presidio Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |