Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.65 |
| ▸ | PRKACG | P22612 | 3/20 | 0.65 |
| ▸ | PRKACB | P22694 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647246 | 0.87 | PRKACA (0.65) | PRKACAPRKACGPRKACBSMN1; SMN2ROCK2 | |
| SCHEMBL12779514 | 0.84 | BTK (0.52) | PRKACAPRKACGPRKACBSMN1; SMN2BTK | |
| SCHEMBL12779737 | 0.83 | ROCK2 (0.67) | PRKACAPRKACGPRKACBROCK2ROCK1 | |
| SCHEMBL1647171 | 0.83 | PRKACA (0.61) | PRKACAPRKACGPRKACBSMN1; SMN2ROCK2 | |
| SCHEMBL12779421 | 0.81 | PRKACA (0.77) | PRKACAPRKACGPRKACBSMN1; SMN2ROCK2 | |
| SCHEMBL13362826 | 0.79 | MMP13 (0.51) | ROCK2ROCK1MAPTBTKTNIK | |
| SCHEMBL13457054 | 0.79 | ROCK2 (0.64) | ROCK2ROCK1BTKTNIKPDGFRB | |
| SCHEMBL3128936 | 0.79 | ROCK2 (0.62) | ROCK2BTKPDGFRBKITFLT3 | |
| SCHEMBL1647780 | 0.79 | PRKACA (1.00) | PRKACAPRKACGPRKACBSMN1; SMN2ROCK2 | |
| SCHEMBL1648102 | 0.77 | CLK1 (0.52) | PRKACAPRKACGPRKACBSMN1; SMN2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |