Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648864 | 0.81 | ROCK2 (0.62) | CLK1ROCK2ROCK1PRKACAPRKACG | |
| SCHEMBL1648756 | 0.80 | AURKA (0.63) | CLK1ROCK2ROCK1PRKACAGRK5 | |
| SCHEMBL19723671 | 0.79 | CLK1 (0.61) | CLK1ROCK2MAPTROCK1PRKACA | |
| SCHEMBL1647896 | 0.77 | PRKACA (0.65) | ROCK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL12779737 | 0.77 | ROCK2 (0.67) | ROCK2TNIKBTKMAPTROCK1 | |
| SCHEMBL13362826 | 0.76 | MMP13 (0.51) | ROCK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL13457054 | 0.76 | ROCK2 (0.64) | ROCK2TNIKBTKPDGFRBKIT | |
| SCHEMBL3128936 | 0.76 | ROCK2 (0.62) | ROCK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL12779960 | 0.73 | CIT (0.49) | ROCK2TNIKMAPTROCK1PRKACA | |
| SCHEMBL12779969 | 0.72 | LIMK1 (0.49) | ROCK2JAK3JAK2MAPTROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |