Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | IL6ST | P40189 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 7/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450465 | 0.87 | IL6ST (0.46) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL4450467 | 0.87 | IL6ST (0.46) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL24864245 | 0.87 | IL6ST (0.46) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL21153492 | 0.86 | ALDH1A1 (0.51) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL21153784 | 0.86 | ALDH1A1 (0.51) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL13040580 | 0.86 | ALDH1A1 (0.44) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL16072765 | 0.86 | ALDH1A1 (0.42) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL16796724 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL16796721 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL18844458 | 0.84 | ALDH1A1 (0.49) | ALDH1A1GAAHTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376410-B2 | (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2016-06-28 | — | — | US | disclosed |
| US-9376410-B2 | (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2016-06-28 | — | — | US | disclosed |
| US-20150284351-A1 | (2R)-2-DEOXY-2,2-DISUBSTITUTED-RIBONO-1,4-LACTONE AND PREPARATION METHOD AND USE THEREOF | TOPHARMAN SHANDONG CO., LTD. (CN) | 2015-10-08 | — | — | US | disclosed |
| US-20150284351-A1 | (2R)-2-DEOXY-2,2-DISUBSTITUTED-RIBONO-1,4-LACTONE AND PREPARATION METHOD AND USE THEREOF | TOPHARMAN SHANDONG CO., LTD. (CN) | 2015-10-08 | — | — | US | disclosed |
| WO-2014056442-A1 | (2R)-2-DEOXY-2,2-DISUBSTITUTE-1,4-RIBOSE LACTONE AND PREPARATION METHOD AND USE THEREOF | 上海特化医药科技有限公司 (CN) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284351-A1 | (2R)-2-DEOXY-2,2-DISUBSTITUTED-RIBONO-1,4-LACTONE AND PREPARATION METHOD AND USE THEREOF | RNASEL, RNASE1, RRM1 | ALDH1A1 1328/4885GAA 862/4885HTT 3727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.