Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967918 | 0.84 | GPR17 (0.43) | MAP2K4CDK2PDPK1YTHDC1FEN1 | |
| SCHEMBL8877409 | 0.83 | MAP2K4 (0.44) | MAP2K4TTKCDK2KDRPLK4 | |
| SCHEMBL16252836 | 0.81 | MAP2K4 (0.43) | MAP2K4TTKKDRLCKCSF1R | |
| SCHEMBL2723270 | 0.81 | MAP2K4 (0.49) | MAP2K4TTKCDK2KDRABL1 | |
| SCHEMBL2599805 | 0.79 | KDM4E (0.60) | CDK2YTHDC1KDM4ESTAT3HIF1A | |
| SCHEMBL20488957 | 0.79 | NTRK1 (0.35) | MAP2K4TTKCDK2KDRPLK4 | |
| SCHEMBL2021782 | 0.78 | KDR (0.52) | MAP2K4TTKCDK2KDRPLK4 | |
| SCHEMBL4777030 | 0.78 | MAP2K4 (0.41) | MAP2K4TTKCDK2KDRPLK4 | |
| SCHEMBL2721094 | 0.76 | NOS1 (0.44) | MAP2K4TTKCDK2KDM4ESTAT3 | |
| SCHEMBL17024756 | 0.75 | DYRK1B (0.43) | KDRPLK4AURKAJAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |