Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721250 | 0.87 | NOS1 (0.45) | NOS1KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL837904 | 0.78 | GAA (0.53) | NOS1KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL1253994 | 0.76 | NOS1 (0.50) | NOS1KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL8877409 | 0.76 | MAP2K4 (0.44) | KDM4EMEN1CYP1A2CYP3A4MAPT | |
| SCHEMBL1648452 | 0.76 | MAP2K4 (0.44) | NOS1KDM4EMAP2K4TTKSTAT3 | |
| SCHEMBL28775981 | 0.76 | THRB (0.53) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL29732926 | 0.76 | THRB (0.53) | MEN1MAPTKMT2AALDH1A1MAPK1 | |
| Methyl Alcohol SCHEMBL27939963 | 0.76 | NOS1 (0.46) | NOS1KDM4EMEN1CYP1A2CYP3A4 | |
| SCHEMBL16252836 | 0.75 | MAP2K4 (0.43) | KDM4EMAP2K4TTKPARP1STAT3 | |
| SCHEMBL1172395 | 0.75 | NOS1 (0.49) | NOS1KDM4EMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447080-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2016-09-20 | — | — | US | disclosed |
| US-9365554-B2 | Viral polymerase inhibitors | AVIRAGEN THERAPEUTICS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9120775-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2015-09-01 | — | — | US | disclosed |
| US-20150175592-A1 | Viral Polymerase Inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2015-06-25 | — | — | US | disclosed |
| US-20150065445-A1 | Viral Polymerase Inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2015-03-05 | — | — | US | disclosed |
| US-8785478-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2014-07-22 | — | — | US | disclosed |
| WO-2013152391-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | WO | disclosed |
| US-20130274218-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | US | disclosed |
| WO-2013152392-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | WO | disclosed |
| US-20130274179-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | US | disclosed |
| US-8546389-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2013-10-01 | — | — | US | disclosed |
| EP-2630128-A1 | VIRAL POLYMERASE INHIBITORS | Biota Scientific Management Pty Ltd (AU) | 2013-08-28 | — | — | EP | disclosed |
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD | 2012-06-07 | — | — | US | disclosed |
| WO-2012051659-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175592-A1 | Viral Polymerase Inhibitors | POLR2E, POLM, POLR2H | NOS1 662/4885KDM4E 4547/4885MEN1 4869/4885 |
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | NOS1 575/4885KDM4E 4521/4885MEN1 4868/4885 |
| US-20150065445-A1 | Viral Polymerase Inhibitors | POLR2E, POLM, POLR2H | NOS1 662/4885KDM4E 4547/4885MEN1 4869/4885 |
| US-20130274218-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | NOS1 662/4885KDM4E 4547/4885MEN1 4869/4885 |
| US-20130274179-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | NOS1 662/4885KDM4E 4547/4885MEN1 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.