Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790284 | 0.90 | BTK (0.39) | BTKSCN9ASCN5ACCNB2CDK1 | |
| SCHEMBL13147853 | 0.81 | CCNB2 (0.39) | BTKSCN9ASCN5ACCNB2CDK1 | |
| SCHEMBL29773883 | 0.74 | CHRM2 (0.49) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16597821 | 0.72 | GABRG2 (0.42) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL19805011 | 0.71 | GABRG2 (0.37) | BTKCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL19806740 | 0.71 | DDB1 (0.42) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL27905863 | 0.70 | CHRM2 (0.49) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL26818488 | 0.69 | GPR119 (0.40) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL23104799 | 0.69 | CHRM2 (0.45) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL22251171 | 0.69 | ELANE (0.40) | BTKGPR119ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033342-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2016-06-22 | — | — | EP | disclosed |
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | GRUENENTHAL GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | GRUENENTHAL GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | GRUENENTHAL GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| WO-2015022073-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | AADAC, PRRC2C, PRRC2A | BTK 1758/4885SCN9A 3127/4885SCN5A 3533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.