Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29773883 | 0.84 | CHRM2 (0.49) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL19805011 | 0.81 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL16637537 | 0.81 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL31017644 | 0.79 | CHRM2 (0.46) | DDB1CRBNGABRG2GABRB3GABRA5 | |
| SCHEMBL22978317 | 0.78 | GABRG2 (0.39) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL31017633 | 0.78 | BRD4 (0.42) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL23319531 | 0.77 | MAPT (0.43) | DDB1CRBNGABRG2GABRB3GABRA5 | |
| SCHEMBL22960801 | 0.77 | MAPT (0.39) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL16637427 | 0.77 | MAPT (0.41) | GABRG2GABRB3GABRA5GPR119GABRA1 | |
| SCHEMBL27905863 | 0.76 | CHRM2 (0.49) | GABRG2GABRB3GABRA5GPR119GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-12-15 | — | — | US | disclosed |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-11-17 | — | — | US | disclosed |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
| WO-2018015549-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | AC IMMUNE S.A. (CH) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN2, PSEN1 | DDB1 1392/4885CRBN 844/4885GABRG2 2609/4885 |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN2, PSEN1 | DDB1 1392/4885CRBN 844/4885GABRG2 2609/4885 |
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN1, PSEN2 | DDB1 1175/4885CRBN 918/4885GABRG2 2766/4885 |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN1, PSEN2 | DDB1 1175/4885CRBN 918/4885GABRG2 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.