Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16486457 | 0.78 | PTK2 (0.61) | HTTLMNAMAPK1TSHRALDH1A1 | |
| SCHEMBL11511915 | 0.78 | LMNA (0.61) | SMN1; SMN2HTTNPSR1LMNATHRB | |
| SCHEMBL15983661 | 0.75 | HIF1A (1.00) | SMN1; SMN2HTTNPSR1LMNAHIF1A | |
| SCHEMBL6404885 | 0.73 | TSHR (0.72) | SMN1; SMN2HTTNPSR1LMNACRHBP | |
| SCHEMBL27530845 | 0.72 | SMN1; SMN2 (0.79) | SMN1; SMN2HTTNPSR1LMNATHRB | |
| SCHEMBL6403463 | 0.72 | CYP3A4 (0.73) | SMN1; SMN2NPSR1THRBHPGDMAPT | |
| SCHEMBL11919929 | 0.72 | NPSR1 (0.69) | SMN1; SMN2HTTNPSR1LMNATHRB | |
| SCHEMBL6406121 | 0.71 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTNPSR1LMNAHPGD | |
| SCHEMBL31411197 | 0.71 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTNPSR1LMNACRHBP | |
| SCHEMBL11919922 | 0.71 | THRB (0.60) | SMN1; SMN2HTTNPSR1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015021943-A9 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015021943-A1 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-02-19 | — | — | WO | disclosed |