Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NAT1 | P18440 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884336 | 0.84 | HNF4A (0.64) | ALDH1A1KDM4ELMNAFABP3FABP4 | |
| SCHEMBL5500414 | 0.84 | KDM4C (0.45) | NAT1BCAT2CNR2SMN1; SMN2GPR84 | |
| SCHEMBL2704845 | 0.84 | BCAT2 (0.61) | ALDH1A1KDM4EPOLBTSHRNAT1 | |
| SCHEMBL11613856 | 0.82 | POLB (0.47) | ALDH1A1KDM4ELMNAPOLBHNF4A | |
| SCHEMBL28479627 | 0.80 | MAPT (0.40) | ALDH1A1POLBNAT1BCAT2CNR2 | |
| SCHEMBL1649386 | 0.79 | TUBB4A (0.49) | ALDH1A1KDM4EFABP3FABP4FABP5 | |
| Benzene SCHEMBL1403559 | 0.78 | HNF4A (0.69) | ALDH1A1ALOX15KDM4EPOLBFABP3 | |
| Benzene SCHEMBL28480917 | 0.78 | HNF4A (0.69) | ALDH1A1ALOX15KDM4EPOLBFABP3 | |
| SCHEMBL133057 | 0.78 | HNF4A (0.69) | ALDH1A1ALOX15KDM4EPOLBFABP3 | |
| SCHEMBL18759613 | 0.78 | HNF4A (0.63) | ALDH1A1ALOX15KDM4EFABP3FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | claimed |
| CN-114989085-A | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2022-09-02 | — | — | CN | disclosed |