SCHEMBL16488115

SCHEMBL16488115

COc1cc(O)cc2nc(-c3ccc(C)c(C)c3)ccc12

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.47
ESR2 Q92731 2/20 0.47
TDO2 P48775 1/20 0.44
KDM4E B2RXH2 5/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 3/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 1/20 0.42
LMNA P02545 2/20 0.41
HPGD P15428 2/20 0.41
RAC1 P63000 2/20 0.41
HTT P42858 1/20 0.41
TP53 P04637 1/20 0.40
PDE4A P27815 1/20 0.40
PDE4D Q08499 1/20 0.40
KMO O15229 1/20 0.40
PDGFRB P09619 1/20 0.38
PDGFRA P16234 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13870928 0.85 KDM4E (0.53) ESR1ESR2TDO2KDM4ESMN1; SMN2
SCHEMBL16488117 0.83 ESR1 (0.46) ESR1ESR2TDO2KDM4ESMN1; SMN2
SCHEMBL16488116 0.83 TDO2 (0.49) ESR1ESR2TDO2KDM4ESMN1; SMN2
SCHEMBL16487806 0.82 TP53 (0.43) ESR1ESR2TDO2KDM4ESMN1; SMN2
SCHEMBL13870944 0.80 KATNA1 (0.44) TDO2KDM4ESMN1; SMN2ALDH1A1MAPT
SCHEMBL13870939 0.77 KDM4E (0.55) KDM4ESMN1; SMN2ALDH1A1MAPTNPC1
SCHEMBL13870917 0.72 NPC1 (0.47) KDM4ESMN1; SMN2ALDH1A1MAPTNPC1
SCHEMBL13870894 0.72 NPC1 (0.47) KDM4ESMN1; SMN2ALDH1A1MAPTNPC1
SCHEMBL16487820 0.71 NPC1 (0.39) ESR1ESR2KDM4ESMN1; SMN2ALDH1A1
SCHEMBL13870820 0.71 KDM4E (0.49) ESR1ESR2TDO2KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956737-B2 Red phosphorescent compound and organic electroluminescent device using the same LG DISPLAY CO., LTD. (KR) 2015-02-17 US disclosed