Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 7/20 | 0.50 |
| ▸ | CA2 | P00918 | 7/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28182817 | 0.83 | TDP1 (1.00) | TDP1APPALOX5KEAP1ALDH1A1 | |
| SCHEMBL29699656 | 0.81 | TDP1 (0.74) | TDP1APPALOX5ALDH1A1 | |
| SCHEMBL9367557 | 0.80 | TDP1 (0.92) | TDP1APPALOX5KEAP1ALDH1A1 | |
| SCHEMBL17879697 | 0.80 | CA1 (0.68) | TDP1APPCA1CA2CA4 | |
| SCHEMBL27807272 | 0.79 | TDP1 (0.89) | TDP1APPALOX5KEAP1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL11481573 | 0.79 | TDP1 (0.89) | TDP1APPALOX5KEAP1ALDH1A1 | |
| SCHEMBL2443821 | 0.78 | KEAP1 (0.54) | TDP1APPCA1CA2CA4 | |
| SCHEMBL1404476 | 0.78 | CA1 (0.55) | TDP1CA1CA2CA4ALDH1A1 | |
| SCHEMBL18668829 | 0.78 | TDP1 (0.79) | TDP1APPALOX5KEAP1ALDH1A1 | |
| SCHEMBL4015185 | 0.77 | TDP1 (0.57) | TDP1APPALOX5ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502938-B1 | Antibodies and immunoconjugates and uses therefor | GENENTECH INC (US) | 2015-02-18 | — | — | EP | disclosed |