Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | KDM6B | O15054 | 1/20 | 0.60 |
| ▸ | KDM4A | O75164 | 1/20 | 0.60 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.60 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922525 | 0.88 | LTA4H (0.56) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL16489564 | 0.86 | KDM4C (0.56) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL11098575 | 0.83 | ALDH1A1 (0.54) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL19771393 | 0.83 | ALDH1A1 (0.54) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| Hydrochloric Acid SCHEMBL10508061 | 0.82 | ALDH1A1 (0.53) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| Hydrochloric Acid SCHEMBL7652650 | 0.82 | KDM6B (0.61) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL22191378 | 0.79 | KDM4C (0.60) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL3884069 | 0.79 | ADRA2C (0.64) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL30894547 | 0.79 | ADRA2C (0.64) | KDM4CKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL3872334 | 0.78 | LTA4H (0.60) | KDM4CKDM4EBACE1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
| WO-2015022332-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | WO | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051208-A1 | PYRIDINONES | MKI67, XDH, CDK6 | KDM4C 769/4885KDM4E 1683/4885KDM6B 362/4885 |
| US-20150246919-A1 | PYRIDINONES | MKI67, XDH, CDK6 | KDM4C 769/4885KDM4E 1683/4885KDM6B 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.