Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 4/20 | 0.54 |
| ▸ | PLG | P00747 | 3/20 | 0.54 |
| ▸ | PLAT | P00750 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934458 | 0.92 | ABCG2 (0.53) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5934557 | 0.90 | TRPV1 (0.51) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16495372 | 0.88 | TRPV1 (0.64) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16496431 | 0.87 | TP53 (0.65) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5934783 | 0.87 | CNR1 (0.58) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16495683 | 0.86 | ROCK2 (0.61) | SMN1; SMN2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL5934638 | 0.85 | TRPV1 (0.58) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5934208 | 0.85 | TP53 (0.68) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5934400 | 0.85 | HPGDS (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5934485 | 0.85 | NPC1 (0.52) | SMN1; SMN2MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |