Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Eprozinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 8/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eprozinol SCHEMBL250679 | 0.97 | HTR1A (0.60) | HTR1AGAASLC6A4SLC6A3 | |
| Eprozinol SCHEMBL317704 | 0.96 | HTR1A (0.58) | HTR1AGAASLC6A4SLC6A3 | |
| Eprozinol SCHEMBL6235398 | 0.96 | HTR1A (0.58) | HTR1AGAASLC6A4SLC6A3 | |
| Zipeprol SCHEMBL1651193 | 0.80 | GAA (0.44) | GAA | |
| SCHEMBL17771711 | 0.80 | GAA (0.61) | GAASLC6A3 | |
| SCHEMBL7428354 | 0.78 | GAA (0.73) | HTR1AGAASLC6A4SLC6A3 | |
| Zipeprol SCHEMBL364352 | 0.77 | GAA (0.47) | GAA | |
| SCHEMBL17771721 | 0.77 | ALDH1A1 (0.49) | GAA | |
| Zipeprol SCHEMBL5563283 | 0.76 | GAA (0.46) | GAA | |
| Zipeprol SCHEMBL363879 | 0.76 | GAA (0.46) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |