Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenglutarimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 19/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenglutarimide SCHEMBL250700 | 0.97 | CYP19A1 (0.56) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| Glutethimide SCHEMBL113708 | 0.80 | CYP19A1 (0.72) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| Glutethimide SCHEMBL21119240 | 0.80 | CYP19A1 (0.72) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| Glutethimide SCHEMBL113709 | 0.80 | CYP19A1 (0.72) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL11847657 | 0.75 | ALDH1A1 (0.54) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| Glutethimide SCHEMBL28781825 | 0.74 | CYP19A1 (0.63) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL17471628 | 0.74 | CYP19A1 (0.53) | CYP19A1ALDH1A1 | |
| SCHEMBL6246501 | 0.73 | CYP19A1 (0.52) | CYP19A1ALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL10920499 | 0.73 | SIGMAR1 (0.43) | ALDH1A1 | |
| SCHEMBL11929003 | 0.72 | SIGMAR1 (0.40) | ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |