Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919880 | 0.84 | PLA2G2D (0.48) | MEN1RAB9AKMT2ASERPINE1TRPV1 | |
| SCHEMBL16503581 | 0.83 | AKR1C3 (0.36) | MEN1RAB9AKMT2AAKR1C3AKR1C2 | |
| SCHEMBL16503577 | 0.80 | ESR1 (0.34) | LMNAMEN1KMT2ATRPV1MAPT | |
| SCHEMBL7911019 | 0.80 | PLAU (0.47) | MEN1RAB9AKMT2AMAPTPLAU | |
| SCHEMBL7923148 | 0.75 | HTR5A (0.50) | — | |
| SCHEMBL16502526 | 0.75 | GRM2 (0.47) | MEN1RAB9AKMT2AAKR1C3AKR1C2 | |
| SCHEMBL16503575 | 0.73 | GABRG2 (0.35) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL16503550 | 0.73 | KDM4E (0.36) | SMN1; SMN2MEN1RAB9AKMT2AF2 | |
| SCHEMBL16503496 | 0.72 | HTR2C (0.43) | LMNASMN1; SMN2RAB9AMAPTF2 | |
| SCHEMBL7918358 | 0.71 | TRPV1 (0.46) | RAB9ASERPINE1TRPV1PLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |