Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 5/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916768 | 0.84 | KDM4E (0.38) | KDM4ENPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL16502518 | 0.84 | PLA2G2D (0.44) | KDM4ENPC1RAB9ASMN1; SMN2RORC | |
| SCHEMBL16502514 | 0.80 | TP53 (0.41) | KDM4ENPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL7916763 | 0.80 | RAB9A (0.35) | KDM4ENPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL7915692 | 0.76 | SLC9A1 (0.46) | — | |
| SCHEMBL18342657 | 0.73 | KDM4E (0.34) | KDM4ENPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL16503582 | 0.73 | LMNA (0.34) | RAB9ASMN1; SMN2MEN1KMT2AF2 | |
| SCHEMBL16503571 | 0.72 | MCL1 (0.35) | KDM4ERORCMEN1KMT2A | |
| SCHEMBL16503581 | 0.71 | AKR1C3 (0.36) | KDM4ERAB9ACASP3MEN1KMT2A | |
| SCHEMBL7921972 | 0.71 | MEN1 (0.40) | KDM4ENPC1RAB9ASMN1; SMN2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |