Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.34 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915371 | 0.85 | PLA2G2D (0.44) | ESR1ESR2HSD17B14THRBMEN1 | |
| SCHEMBL16502604 | 0.81 | LCK (0.45) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL16503582 | 0.80 | LMNA (0.34) | MEN1LMNAMAPTKMT2ATRPV1 | |
| SCHEMBL7918251 | 0.77 | HTR5A (0.50) | — | |
| SCHEMBL16503581 | 0.77 | AKR1C3 (0.36) | MEN1ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL7915369 | 0.73 | PLA2G2D (0.46) | HSD17B14THRBMEN1ALDH1A1LMNA | |
| SCHEMBL16503571 | 0.71 | MCL1 (0.35) | MEN1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL16502500 | 0.70 | PLA2G2D (0.49) | MEN1KMT2ATRPV1 | |
| SCHEMBL7921825 | 0.70 | PLA2G2D (0.46) | HSD17B14THRBMEN1ALDH1A1LMNA | |
| SCHEMBL16503575 | 0.70 | GABRG2 (0.35) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |