SCHEMBL16503763

SCHEMBL16503763

Cc1cc(C#N)cc(C(=O)NC(C)C)c1NC(=O)c1cnc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ EPAS1 Q99814 1/20 0.37
▸ SLC2A1 P11166 11/20 0.36
▸ SLC2A3 P11169 11/20 0.36
▸ SLC2A4 P14672 11/20 0.36
▸ PDE4B Q07343 3/20 0.34
▸ PDE4A P27815 2/20 0.34
▸ PDE4C Q08493 2/20 0.34
▸ PDE4D Q08499 2/20 0.34
▸ PDE3B Q13370 1/20 0.34
▸ PDE11A Q9HCR9 1/20 0.34
▸ SLC2A2 P11168 4/20 0.34
▸ FNTA P49354 1/20 0.34
▸ FNTB P49356 1/20 0.34
▸ NTRK1 P04629 1/20 0.34
▸ DGAT2 Q96PD7 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16572256 0.95 EPAS1 (0.35) EPAS1SLC2A1SLC2A3SLC2A4PDE4B
SCHEMBL16503751 0.93 EPAS1 (0.38) EPAS1SLC2A1SLC2A3SLC2A4PDE4B
SCHEMBL16503748 0.92 EPAS1 (0.41) EPAS1PDE4BPDE4APDE4CPDE4D
SCHEMBL16503749 0.92 EPAS1 (0.37) EPAS1SLC2A1SLC2A3SLC2A4PDE4B
SCHEMBL16503752 0.91 SLC2A1 (0.41) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503760 0.86 SLC2A1 (0.35) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL1696948 0.84 EPAS1 (0.42) EPAS1PDE4BPDE4APDE4CPDE4D
SCHEMBL16503744 0.83 SLC2A1 (0.35) SLC2A1SLC2A3SLC2A4PDE4BPDE4A
SCHEMBL16503753 0.83 EPAS1 (0.41) EPAS1PDE4BPDE4APDE4CPDE4D
SCHEMBL16503738 0.83 EPAS1 (0.44) EPAS1SLC2A1SLC2A3SLC2A4PDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES ANTXR2, NQO2, ACLY EPAS1 3339/4885SLC2A1 4190/4885SLC2A3 4342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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