Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12791153 | 1.00 | TERT (0.43) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL17433022 | 0.90 | TERT (0.38) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL12791476 | 0.88 | LMNA (0.48) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL12791503 | 0.88 | LMNA (0.48) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL25135193 | 0.87 | ICMT (0.49) | LMNAICMTALBCA12CA9 | |
| SCHEMBL10002238 | 0.87 | ICMT (0.49) | LMNAICMTALBCA12CA9 | |
| SCHEMBL12791491 | 0.84 | LMNA (0.44) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL8165555 | 0.84 | LMNA (0.44) | TERTLMNAICMTALBMCL1 | |
| SCHEMBL17433013 | 0.83 | TERT (0.35) | TERTLMNAICMTALBITGB2 | |
| SCHEMBL19628881 | 0.82 | KDM5A (0.56) | ICMTALBHSD17B10KDM5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |