Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16504753 | 1.00 | CTSS (0.45) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504797 | 1.00 | CTSS (0.45) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504470 | 1.00 | CTSS (0.45) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504471 | 1.00 | CTSS (0.45) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL23626318 | 0.92 | CTSK (0.49) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504677 | 0.90 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16572287 | 0.90 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16572281 | 0.90 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504607 | 0.90 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504508 | 0.90 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035923-B1 | DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-9963427-B2 | Dithiol mucolytic agents | PARION SCIENCES, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20160194278-A1 | DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-07-07 | — | — | US | disclosed |
| EP-3035923-A2 | DITHIOL MUCOLYTIC AGENTS | Parion Sciences, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| US-9346753-B2 | Dithiol mucolytic agents | PARION SCIENCES, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| WO-2015026601-A2 | DITHIOL MUCOLYTIC AGENTS | JOHNSON MICHAEL R (US) | 2015-02-26 | — | — | WO | disclosed |
| US-20150056305-A1 | DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194278-A1 | DITHIOL MUCOLYTIC AGENTS | MUC1, DNASE1, MMP8 | CTSS 698/4885CTSK 682/4885CA1 566/4885 |
| US-20150056305-A1 | DITHIOL MUCOLYTIC AGENTS | MUC1, DNASE1, MMP8 | CTSS 698/4885CTSK 682/4885CA1 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.