Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Chloracyzine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.64 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | BCHE | P06276 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloracyzine SCHEMBL309939 | 0.98 | ALDH1A1 (0.77) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| Chloracyzine SCHEMBL29388455 | 0.98 | ALDH1A1 (0.77) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| Chloracyzine SCHEMBL30719025 | 0.98 | ALDH1A1 (0.77) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| Chloracyzine SCHEMBL11614590 | 0.97 | ALDH1A1 (0.79) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| SCHEMBL6313879 | 0.87 | BCHE (0.65) | ALDH1A1KDM4EBCHEACHECHRM2 | |
| Hydrochloric Acid SCHEMBL5499595 | 0.86 | BCHE (0.66) | ALDH1A1KDM4EBCHEACHELMNA | |
| Fluacizine SCHEMBL1650048 | 0.84 | MEN1 (0.59) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| Fluacizine SCHEMBL49497 | 0.81 | MEN1 (0.61) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| Fluacizine SCHEMBL29388364 | 0.81 | MEN1 (0.61) | ALDH1A1KDM4EBCHEACHEMEN1 | |
| SCHEMBL11171388 | 0.81 | BCHE (0.75) | ALDH1A1KDM4EBCHEACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |