Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednicarbate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 1.00 |
| ▸ | PGR | P06401 | 8/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL6 | P05231 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | GLUL | P15104 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednicarbate SCHEMBL3942 | 1.00 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL3941 | 1.00 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL5483489 | 1.00 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL6466947 | 0.98 | NR3C1 (0.97) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL30697296 | 0.95 | NR3C1 (0.91) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11430405 | 0.95 | NR3C1 (0.90) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11425522 | 0.94 | NR3C1 (0.89) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL423275 | 0.94 | NR3C1 (0.89) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11431033 | 0.94 | NR3C1 (0.88) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL20365864 | 0.94 | PGR (0.88) | NR3C1PGRHIF1ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200325543-A1 | DIAGNOSTIC METHOD | TOLREMO THERAPEUTICS AG (CH) | 2020-10-15 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |