Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16508899 | 0.88 | GNAO1 (0.46) | GNAI3GNAO1GNAI1 | |
| SCHEMBL12423904 | 0.85 | DRD2 (0.43) | DRD2SMN1; SMN2CARM1PRMT6GNAI3 | |
| SCHEMBL12535764 | 0.83 | NCF1 (0.38) | GNAI3GNAO1GNAI1 | |
| SCHEMBL11598833 | 0.78 | SLC18A3 (0.41) | CARM1PRMT6KDM4ECYP1A2CYP3A4 | |
| SCHEMBL22738276 | 0.76 | DRD2 (0.40) | DRD2SMN1; SMN2 | |
| SCHEMBL4762635 | 0.76 | DRD2 (0.46) | DRD2GNAI3GNAO1GNAI1SLC6A4 | |
| SCHEMBL14837985 | 0.75 | NCF1 (0.35) | GNAI3GNAO1GNAI1 | |
| SCHEMBL24491624 | 0.75 | DRD2 (0.39) | DRD2SMN1; SMN2CARM1PRMT6GNAI3 | |
| SCHEMBL17518758 | 0.75 | DRD2 (0.40) | DRD2SMN1; SMN2CARM1PRMT6 | |
| SCHEMBL24491629 | 0.75 | DRD2 (0.39) | DRD2SMN1; SMN2CARM1PRMT6GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294780-A1 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294780-A1 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS | ESR2, IGF1R, ESRRA | DRD2 3404/4885SMN1; SMN2 3467/4885CARM1 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.