Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922007 | 0.90 | KDM4E (0.69) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509249 | 0.90 | MAPT (0.50) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509223 | 0.90 | RAB9A (0.50) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509242 | 0.87 | KDM4E (0.49) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509264 | 0.87 | KDM4E (0.48) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509297 | 0.86 | NPC1 (0.47) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509325 | 0.85 | PARP1 (0.53) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16509210 | 0.85 | PRSS1 (0.48) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL14105812 | 0.83 | CHEK2 (0.50) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL12325450 | 0.82 | NPBWR1 (0.56) | KDM4ERAB9ANPC1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306611-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306611-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | KDM4E 360/4885RAB9A 4067/4885NPC1 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.