Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.58 |
| ▸ | PNMT | P11086 | 7/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | CD44 | P16070 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518127 | 0.85 | PRCP (0.55) | PRCPPNMTCD44MAOBHDAC1 | |
| SCHEMBL16518013 | 0.83 | PRCP (0.59) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518130 | 0.82 | PNMT (0.53) | PRCPPNMTHDAC1HDAC6HDAC5 | |
| SCHEMBL16518079 | 0.81 | PRCP (0.61) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518131 | 0.80 | PRCP (0.50) | PRCPPNMTCD44MAOBHDAC1 | |
| SCHEMBL16518022 | 0.80 | PRCP (0.56) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL3052029 | 0.78 | PNMT (0.61) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518170 | 0.78 | HTR5A (0.41) | PRCPPNMTHTR5A | |
| SCHEMBL16518140 | 0.77 | PRCP (0.52) | PRCPPNMTCD44MAOBADRA2A | |
| Hydrochloric Acid SCHEMBL2258194 | 0.76 | PNMT (0.59) | PRCPPNMTCD44MAOBADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |