Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518134 | 0.85 | PARP1 (0.41) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| SCHEMBL16518155 | 0.80 | HTR7 (0.47) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| SCHEMBL2258843 | 0.80 | HTR2C (0.47) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| SCHEMBL16518152 | 0.79 | HTR5A (0.42) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| Hydrochloric Acid SCHEMBL1198541 | 0.78 | HTR2C (0.46) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| SCHEMBL16518132 | 0.78 | PRCP (0.58) | HTR5APNMTPRCP | |
| SCHEMBL16518153 | 0.77 | HTR5A (0.41) | HTR5AHTR2CHTR2AHTR2BPNMT | |
| SCHEMBL16518181 | 0.76 | HTR7 (0.43) | HTR2CHTR2AHTR2BHTR6PARP1 | |
| SCHEMBL16518157 | 0.76 | PNMT (0.45) | HTR2CHTR2AHTR2BPNMTPRCP | |
| SCHEMBL16518159 | 0.75 | CDC7 (0.39) | HTR2CHTR2AHTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |