Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.70 |
| ▸ | CES1 | P23141 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | RECQL | P46063 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.61 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.60 |
| ▸ | WNT3A | P56704 | 7/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064749 | 0.94 | CES2 (0.61) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL7718179 | 0.92 | ERCC5 (0.59) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL8544013 | 0.91 | CES2 (0.64) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL8962313 | 0.90 | CES2 (0.57) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL5527395 | 0.90 | CES2 (0.57) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL2526232 | 0.89 | CES2 (0.61) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL15979683 | 0.88 | CTNNB1 (0.59) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL27398867 | 0.87 | CES2 (0.59) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL3506264 | 0.87 | CES2 (0.59) | CES2CES1ALDH1A1POLBHPGD | |
| SCHEMBL1933054 | 0.87 | CES2 (0.59) | CES2CES1ALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11839679-B2 | Gamma-diketones for treatment and prevention of aging skin and wrinkles | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-11839679-B2 | Gamma-diketones for treatment and prevention of aging skin and wrinkles | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-11673885-B2 | γ-diketones as Wnt/β-catenin signaling pathway activators | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673885-B2 | γ-diketones as Wnt/β-catenin signaling pathway activators | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230053726-A1 | GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS | VICKERS-SPLICE CO-INVESTMENT LLC (KY) | 2023-02-23 | — | — | US | disclosed |
| US-20220087917-A1 | GAMMA-DIKETONES FOR TREATMENT AND PREVENTION OF AGING SKIN AND WRINKLES | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2022-03-24 | — | — | US | disclosed |
| US-11077046-B2 | Gamma-diketones for treatment and prevention of aging skin and wrinkles | BIOSPLICE THERAPEUTICS, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-11034682-B2 | Gamma-diketones as wnt/β-catenin signaling pathway activators | SAMUMED, LLC (US) | 2021-06-15 | — | — | US | disclosed |
| EP-3283550-B1 | CATALYST CONTAINING AMIDINE GROUPS | SIKA TECH AG (CH) | 2020-12-16 | — | — | EP | disclosed |
| EP-3294803-B1 | GUANIDINE GROUP CONTAINING CATALYST | SIKA TECH AG (CH) | 2020-12-09 | — | — | EP | disclosed |
| US-20110082248-A1 | POLYAMINE HAVING A REDUCED BLUSHING EFFECT, AND USE THEREOF AS A CURING AGENT FOR EPOXY RESINS | SIKA TECHNOLOGY AG (CH) | 2011-04-07 | — | — | US | disclosed |
| EP-2133378-A1 | Polyamine with reduced blushing and its application as hardener for epoxy resin | Sika Technology AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| EP-2133381-A1 | Water soluble amine and its application | Sika Technology AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| EP-0500005-B1 | Process for the preparation of substituted indenes | HOECHST AG (DE) | 1996-02-07 | — | — | EP | disclosed |
| US-5194619-A | PROCESS FOR THE PREPARATION OF SUBSTITUTED INDENES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| EP-0500005-A1 | Process for the preparation of substituted indenes | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-26 | — | — | EP | disclosed |
| EP-0199324-B1 | NEW 2,5-DIARYL TETRYHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0199324-A2 | New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4035395-A | Process for the preparation of ketones | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11077046-B2 | Gamma-diketones for treatment and prevention of aging skin and wrinkles | GLA, DGKG, DGKA | CES2 4435/4885CES1 2510/4885ALDH1A1 985/4885 |
| US-20220087917-A1 | GAMMA-DIKETONES FOR TREATMENT AND PREVENTION OF AGING SKIN AND WRINKLES | GLA, DGKG, DGKA | CES2 4435/4885CES1 2510/4885ALDH1A1 985/4885 |
| US-20110082248-A1 | POLYAMINE HAVING A REDUCED BLUSHING EFFECT, AND USE THEREOF AS A CURING AGENT FOR EPOXY RESINS | SRM, PRMT1, PBRM1 | CES2 1022/4885CES1 1777/4885ALDH1A1 287/4885 |
| US-11839679-B2 | Gamma-diketones for treatment and prevention of aging skin and wrinkles | DGKG, DGKA, DNER | CES2 3982/4885CES1 2355/4885ALDH1A1 1485/4885 |
| US-20230053726-A1 | GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS | GSK3A, GSK3B, WNT1 | CES2 4753/4885CES1 3944/4885ALDH1A1 1019/4885 |
| US-11034682-B2 | Gamma-diketones as wnt/β-catenin signaling pathway activators | GSK3A, GSK3B, WNT1 | CES2 4768/4885CES1 4001/4885ALDH1A1 1024/4885 |
| US-11673885-B2 | γ-diketones as Wnt/β-catenin signaling pathway activators | GSK3A, GSK3B, WNT1 | CES2 4749/4885CES1 3997/4885ALDH1A1 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.