Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25896993 | 0.85 | PBRM1 (0.36) | CYP2C9PBRM1KDM4EMEN1MAPT | |
| SCHEMBL13930558 | 0.82 | ALDH1A1 (0.35) | PBRM1KDM4EALDH1A1HPGDRXRA | |
| SCHEMBL7998384 | 0.78 | PBRM1 (0.37) | CYP2C9PBRM1KDM4EMAPTALDH1A1 | |
| SCHEMBL25119189 | 0.78 | UPP1 (0.39) | CYP2C9PBRM1KDM4EMEN1MAPT | |
| SCHEMBL2492885 | 0.77 | HSD17B10 (0.36) | KDM4EALDH1A1HPGDPOLBTYMS | |
| SCHEMBL7123504 | 0.77 | ALDH1A1 (0.33) | KDM4EMAPTALDH1A1HPGDPOLB | |
| SCHEMBL13930790 | 0.76 | KDM4E (0.32) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9527144 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1HPGDGAAEPHX2 | |
| SCHEMBL17263924 | 0.75 | ALDH1A1 (0.37) | PBRM1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL30067255 | 0.74 | PBRM1 (0.46) | CYP2C9PBRM1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603887-B1 | HIV REPLICATION INHIBITING INDANE SUBSTITUTED PYRIMIDINES | TIBOTEC PHARM LTD (IE) | 2011-04-20 | — | — | EP | disclosed |
| EP-1603887-B1 | HIV REPLICATION INHIBITING INDANE SUBSTITUTED PYRIMIDINES | TIBOTEC PHARM LTD (IE) | 2011-04-20 | — | — | EP | disclosed |
| US-7585870-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC BVBA (BE) | 2009-09-08 | — | — | US | disclosed |
| US-7585870-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC BVBA (BE) | 2009-09-08 | — | — | US | disclosed |
| US-7585870-B2 | HIV replication inhibiting pyrimidines and triazines | TIBOTEC BVBA (BE) | 2009-09-08 | — | — | US | disclosed |
| US-20060142571-A1 | Hiv replication inhibiting pyrimidines and triazines | JANSSEN SCIENCES IRELAND UC (IE) | 2006-06-29 | — | — | US | disclosed |
| EP-1603887-A1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | Tibotec Pharmaceuticals Ltd. (IE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004074261-A1 | HIV REPLICATION INHIBITING PYRIMIDINES AND TRIAZINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142571-A1 | Hiv replication inhibiting pyrimidines and triazines | TYMS, UMPS, DUT | CYP2C9 1547/4885PBRM1 553/4885KDM4E 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.