Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | PDE6C | P51160 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657054 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL5403856 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL10957985 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL6394776 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL6990525 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL5397566 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL10992886 | 0.75 | CYP1A2 (0.51) | ALDH1A1NPSR1L3MBTL1GAAMAPK1 | |
| SCHEMBL480505 | 0.75 | MAPK1 (0.56) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL3829961 | 0.75 | ALDH1A1 (0.65) | ALDH1A1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL1653731 | 0.75 | ALDH1A1 (0.65) | ALDH1A1TSHRNPSR1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240028-B1 | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical | INTRA CELLULAR THERAPIES INC (US) | 2016-07-20 | — | — | EP | disclosed |
| EP-2023729-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9255099-B2 | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-20150197524-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2015-07-16 | — | — | US | disclosed |
| US-20150139903-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | LI PENG (US) | 2015-05-21 | — | — | US | disclosed |
| US-8858911-B2 | Phosphodiesterase 1-targeting tracers and methods | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8846693-B2 | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2485771-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | Intra-Cellular Therapies, Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20120201754-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | INTRA-CELLULAR THERAPIES, INC. | 2012-08-09 | — | — | US | disclosed |
| WO-2011043816-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | INTRA-CELLULAR THERAPIES, INC. (US) | 2011-04-14 | — | — | WO | disclosed |
| EP-2023729-A2 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007143705-A2 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2007-12-13 | — | — | WO | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| EP-0975636-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6-DIONES AS T-CELL PROLIFERATION INHIBITORS | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |
| US-6028074-A | FOR TREATING ALLOGRAFT REJECTION | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-02-22 | — | — | US | disclosed |
| EP-0975636-A1 | NOVEL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046606-A1 | NOVEL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197524-A1 | ORGANIC COMPOUNDS | OPRD1, HTR1D, DRD1 | ALDH1A1 659/4885TSHR 776/4885NPSR1 129/4885 |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | ALDH1A1 903/4885TSHR 3317/4885NPSR1 3337/4885 |
| US-20120201754-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | PDE5A, PDE2A, PDE3A | ALDH1A1 540/4885TSHR 2721/4885NPSR1 841/4885 |
| US-20150139903-A1 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS | PDE5A, PDE2A, PDE3A | ALDH1A1 566/4885TSHR 2869/4885NPSR1 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.