Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724548 | 0.89 | POLB (0.69) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL2652681 | 0.87 | POLB (0.62) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL9422194 | 0.84 | POLB (0.59) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL29323749 | 0.82 | ELANE (0.51) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL9343618 | 0.82 | PKM (1.00) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL14024262 | 0.82 | MAPT (0.77) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL11576441 | 0.80 | MMP2 (0.60) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL3161812 | 0.80 | MAPT (0.74) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL1930857 | 0.80 | MAPT (0.74) | POLBMAPTPKMLMNAALDH1A1 | |
| SCHEMBL13133214 | 0.79 | PKM (0.77) | POLBMAPTPKMLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112135611-A | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-109206346-A | Tertiary amine analog derivative or its salt and its preparation method and application | 复旦大学 | 2019-01-15 | — | — | CN | disclosed |
| WO-2018185675-A1 | SUBSTITUTED OXOAZETIDINE ANALOGUES AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-10-11 | — | — | WO | disclosed |
| CN-106187838-B | Aryl alkynes compound and its preparation method and application | 广东东阳光药业有限公司 | 2018-05-01 | — | — | CN | disclosed |
| WO-2017199103-A1 | BENZAMIDE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-11-23 | — | — | WO | disclosed |
| EP-3131880-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2017-02-22 | — | — | EP | disclosed |
| CN-106232582-A | Aryl and heteroaryl ether compound as ROR gamma modulators | 格兰马克药品股份有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-106187838-A | Arylalkyne hydrocarbon compound and its production and use | 广东东阳光药业有限公司 | 2016-12-07 | — | — | CN | disclosed |
| WO-2015159233-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-10-22 | — | — | WO | disclosed |
| WO-2013171729-A2 | ARYL AND HETEROARYL AMIDE COMPOUNDS AS RORGAMAT MODULATOR | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-11-21 | — | — | WO | disclosed |
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012100734-A1 | COMPOUNDS USEFUL AS RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012100732-A1 | RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS, COMPOSITION CONTAINING THEM AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |