Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418323 | 0.79 | TDP1 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL9450994 | 0.72 | KDM4E (0.53) | LTA4HNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9629603 | 0.72 | SMN1; SMN2 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL8760922 | 0.72 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL423042 | 0.72 | ALOX5 (0.42) | NPC1RAB9ABRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4952574 | 0.72 | ALDH1A1 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL3579084 | 0.71 | TAAR1 (0.44) | SMN1; SMN2 | |
| SCHEMBL627618 | 0.71 | SMN1; SMN2 (0.44) | NPC1RAB9APARP10ALDH1A1SMN1; SMN2 | |
| SCHEMBL27683446 | 0.71 | IDO1 (0.38) | LTA4HNPC1RAB9ASMN1; SMN2HIF1A | |
| SCHEMBL11475913 | 0.71 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HIF1AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486044-A2 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | Achaogen, Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044501-A9 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2012-04-19 | — | — | WO | disclosed |
| WO-2011044501-A2 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2011-04-14 | — | — | WO | disclosed |