Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166268 | 0.89 | RAB9A (0.54) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL166266 | 0.84 | RAB9A (0.54) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL2711947 | 0.76 | HPGD (0.56) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL2711084 | 0.75 | NPC1 (0.58) | RAB9ANPC1HSP90AA1NAMPTALDH1A1 | |
| SCHEMBL166870 | 0.74 | ALDH1A1 (0.56) | RAB9ANPC1SORT1ALDH1A1LMNA | |
| SCHEMBL166396 | 0.72 | NAMPT (0.48) | RAB9ANPC1HSP90AA1NAMPTLMNA | |
| SCHEMBL3507208 | 0.72 | RAB9A (0.50) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL5178524 | 0.71 | RAB9A (0.50) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL13024405 | 0.68 | RAB9A (0.49) | RAB9ANPC1HSP90AA1PDE10ANAMPT | |
| SCHEMBL2201303 | 0.68 | EGLN1 (0.62) | NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| CN-103079562-A | BACE inhibitors for use in the treatment of diabetes | HOFFMANN LA ROCHE | 2013-05-01 | — | — | CN | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |