Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166396 | 0.88 | NAMPT (0.48) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL3507210 | 0.85 | RAB9A (0.51) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL3641653 | 0.84 | NAMPT (0.48) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL3647405 | 0.84 | ENPP2 (0.52) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL2711947 | 0.83 | HPGD (0.56) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL7984987 | 0.82 | KDM4E (0.53) | NPC1KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL166267 | 0.82 | NAMPT (0.46) | NPC1RAB9AKDM4EHSP90AA1NAMPT | |
| SCHEMBL30614797 | 0.82 | ADORA2A (0.54) | NPC1RAB9AHSP90AA1NAMPTALDH1A1 | |
| SCHEMBL2227256 | 0.81 | MAPT (0.67) | NPC1RAB9AKDM4EMAPTHPGD | |
| SCHEMBL7260803 | 0.80 | RAB9A (0.67) | NPC1RAB9AKDM4EHSP90AA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |