Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507210 | 0.90 | RAB9A (0.51) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL3647405 | 0.89 | ENPP2 (0.52) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL3641653 | 0.89 | NAMPT (0.48) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL2711084 | 0.88 | NPC1 (0.58) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL166267 | 0.86 | NAMPT (0.46) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL26926866 | 0.82 | ROCK2 (0.51) | ROCK2GRK2GAANR1H4 | |
| SCHEMBL3686716 | 0.80 | RAB9A (0.48) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL2711113 | 0.79 | NAMPT (0.47) | NAMPTRAB9ANPC1HSP90AA1ROCK2 | |
| SCHEMBL2710128 | 0.78 | NAMPT (0.46) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 | |
| SCHEMBL3510413 | 0.76 | RAB9A (0.47) | NAMPTRAB9ANPC1HSP90AA1SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |