Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 9/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892550 | 0.87 | EPHX1 (0.45) | MEN1KMT2ACASR | |
| SCHEMBL165645 | 0.86 | CASR (0.57) | MEN1KMT2ACASR | |
| SCHEMBL4692485 | 0.86 | CASR (0.57) | MEN1KMT2ACASR | |
| SCHEMBL164926 | 0.83 | HTR2A (0.50) | — | |
| SCHEMBL6895745 | 0.80 | LMNA (0.47) | MEN1KMT2ACASR | |
| SCHEMBL14966126 | 0.79 | CETP (0.52) | MEN1KMT2AMAPK14CETPKDM5A | |
| SCHEMBL3645149 | 0.79 | BCHE (0.52) | MEN1KMT2ACASR | |
| SCHEMBL6892337 | 0.79 | LMNA (0.52) | MEN1KMT2A | |
| SCHEMBL6892177 | 0.78 | ATM (0.42) | CASR | |
| Hydrochloric Acid SCHEMBL7112448 | 0.78 | MEN1 (0.43) | MEN1KMT2ACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |