Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165645 | 1.00 | CASR (0.57) | CASRMEN1KMT2ATAAR1BCHE | |
| SCHEMBL6894740 | 0.87 | TAAR1 (0.46) | CASRMEN1KMT2ATAAR1 | |
| SCHEMBL165514 | 0.86 | MEN1 (0.47) | CASRMEN1KMT2A | |
| SCHEMBL6886251 | 0.86 | TDP1 (0.52) | CASRMEN1KMT2A | |
| SCHEMBL6895745 | 0.84 | LMNA (0.47) | CASRMEN1KMT2ABCHE | |
| SCHEMBL6892337 | 0.82 | LMNA (0.52) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7112448 | 0.81 | MEN1 (0.43) | CASRMEN1KMT2A | |
| SCHEMBL4307949 | 0.81 | KMT2A (0.40) | CASRMEN1KMT2A | |
| SCHEMBL3645149 | 0.81 | BCHE (0.52) | CASRMEN1KMT2ABCHE | |
| SCHEMBL5270682 | 0.80 | MEN1 (0.75) | CASRMEN1KMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871739-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006110668-A1 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-10-19 | — | — | WO | disclosed |