Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16564136 | 0.81 | ALOX15 (0.43) | STIM1ORAI1TRPV1MAPK14MAPT | |
| SCHEMBL16563685 | 0.74 | STIM1 (0.45) | STIM1ORAI1TRPV1MAPK14LMNA | |
| SCHEMBL16563558 | 0.74 | ROCK1 (0.47) | TRPV1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL16564132 | 0.67 | KMT2A (0.44) | MAPTLMNAKDM4ECYP1A2CYP2C19 | |
| SCHEMBL15020867 | 0.67 | ORAI1 (0.55) | STIM1ORAI1 | |
| SCHEMBL15021833 | 0.66 | ORAI1 (0.41) | STIM1ORAI1 | |
| SCHEMBL30096573 | 0.66 | ORAI1 (0.41) | STIM1ORAI1 | |
| SCHEMBL1461086 | 0.66 | ORAI1 (0.43) | STIM1ORAI1 | |
| SCHEMBL15021817 | 0.65 | TRPV3 (0.39) | STIM1ORAI1MAPK14KDM4ENPSR1 | |
| SCHEMBL16563648 | 0.65 | MAPT (0.52) | STIM1ORAI1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |