Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563685 | 0.90 | STIM1 (0.45) | ALOX15MAPK14LMNASTIM1ORAI1 | |
| SCHEMBL16564132 | 0.87 | KMT2A (0.44) | ALOX15LMNAMAPT | |
| SCHEMBL16563648 | 0.83 | MAPT (0.52) | STIM1ORAI1MAPT | |
| SCHEMBL16563558 | 0.83 | ROCK1 (0.47) | ROCK1MAPTTRPV1 | |
| SCHEMBL16563773 | 0.82 | MAPT (0.43) | MAPT | |
| SCHEMBL16563560 | 0.81 | STIM1 (0.41) | MAPK14LMNAFLT3STIM1ORAI1 | |
| SCHEMBL16563759 | 0.78 | STIM1 (0.41) | ALOX15MAPK14FLT3ROCK1STIM1 | |
| SCHEMBL16563837 | 0.78 | ALDH1A1 (0.39) | ALOX15LMNAROCK1MAPTTSHR | |
| SCHEMBL16563942 | 0.76 | KDM4E (0.40) | LMNAROCK1 | |
| SCHEMBL16563570 | 0.76 | HTT (0.40) | ALOX15LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |