Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16564086 | 0.82 | ROCK1 (0.44) | FLT3KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16563759 | 0.77 | STIM1 (0.41) | FLT3ALDH1A1HSD17B10POLB | |
| SCHEMBL15862550 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL28889606 | 0.75 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTMAPK1GAA | |
| SCHEMBL1528634 | 0.73 | MAPT (0.50) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL16563939 | 0.73 | ORAI1 (0.53) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL16564136 | 0.73 | ALOX15 (0.43) | FLT3MAPTRXFP1LMNATSHR | |
| SCHEMBL28401209 | 0.72 | SMN1; SMN2 (0.58) | KDM4EALDH1A1MAPTGAAMEN1 | |
| SCHEMBL30153252 | 0.72 | SMN1; SMN2 (0.58) | KDM4EALDH1A1MAPTGAAMEN1 | |
| SCHEMBL28398322 | 0.71 | MAPT (0.59) | KDM4EMAPTMAPK1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |