Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.53 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15862550 | 0.82 | ALDH1A1 (0.49) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL16563988 | 0.80 | ORAI1 (0.66) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL15862312 | 0.80 | ORAI1 (0.52) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL15873639 | 0.76 | ROCK2 (0.42) | ORAI1STIM1RAB9AABCB1MAPT | |
| SCHEMBL15862687 | 0.76 | ORAI1 (0.50) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL1528634 | 0.75 | MAPT (0.50) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL15862322 | 0.74 | ORAI1 (0.51) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL15862637 | 0.74 | ORAI1 (0.50) | ORAI1STIM1ALDH1A1KDM4EMEN1 | |
| SCHEMBL16563795 | 0.73 | FLT3 (0.42) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL16563900 | 0.72 | MAPT (0.50) | KDM4EMEN1KMT2AMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |