Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.66 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550956 | 0.81 | ORAI1 (0.67) | ORAI1STIM1MEN1KMT2ANPC1 | |
| SCHEMBL16563939 | 0.80 | ORAI1 (0.53) | ORAI1STIM1MEN1KMT2ANPC1 | |
| SCHEMBL29706899 | 0.80 | ORAI1 (1.00) | ORAI1STIM1ROCK1MEN1KMT2A | |
| SCHEMBL1829334 | 0.80 | ORAI1 (1.00) | ORAI1STIM1ROCK1MEN1KMT2A | |
| SCHEMBL16563435 | 0.74 | NPC1 (0.48) | MEN1KMT2ANPC1RAB9ACSNK2A2 | |
| SCHEMBL16564086 | 0.72 | ROCK1 (0.44) | ROCK1MEN1KMT2ACSNK2A2CSNK2A1 | |
| SCHEMBL15862550 | 0.71 | ALDH1A1 (0.49) | ORAI1STIM1MEN1KMT2AMAPK1 | |
| SCHEMBL15395954 | 0.71 | ORAI1 (0.54) | ORAI1STIM1KMT2ANPC1RAB9A | |
| SCHEMBL5550650 | 0.70 | ORAI1 (0.52) | ORAI1STIM1MEN1KMT2ANPC1 | |
| SCHEMBL1823693 | 0.69 | ORAI1 (0.81) | ORAI1STIM1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |