Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | FOXO1 | Q12778 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563900 | 0.82 | MAPT (0.50) | MAPTHPGDSMN1; SMN2TOP1EGFR | |
| SCHEMBL16563988 | 0.74 | ORAI1 (0.66) | NPC1RAB9AFOXO1MAPTHPGD | |
| SCHEMBL16563915 | 0.72 | CYP1A2 (0.54) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL16563947 | 0.72 | HDAC8 (0.47) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3424887 | 0.71 | NPC1 (0.52) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL16563558 | 0.70 | ROCK1 (0.47) | NPC1RAB9AFOXO1MAPTKMT2A | |
| SCHEMBL16563778 | 0.70 | KMT2A (0.43) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL16563791 | 0.69 | POLB (0.53) | MAPTLMNAKMT2AMEN1PKM | |
| SCHEMBL15862550 | 0.69 | ALDH1A1 (0.49) | MAPTHPGDSMN1; SMN2LMNAKMT2A | |
| SCHEMBL22488756 | 0.68 | FOXO1 (0.64) | NPC1RAB9AFOXO1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |