Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 1.00 |
| ▸ | STIM1 | Q13586 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829334 | 1.00 | ORAI1 (1.00) | ORAI1STIM1ABL1LMNATYK2 | |
| SCHEMBL1823693 | 0.89 | ORAI1 (0.81) | ORAI1STIM1ABL1LMNAKCNMA1 | |
| SCHEMBL1828278 | 0.88 | ORAI1 (0.79) | ORAI1STIM1ABL1LMNATYK2 | |
| SCHEMBL16363185 | 0.88 | ORAI1 (0.78) | ORAI1STIM1ABL1LMNAKCNMA1 | |
| SCHEMBL18774781 | 0.84 | STIM1 (0.73) | ORAI1STIM1LMNAL3MBTL1MEN1 | |
| SCHEMBL2785071 | 0.84 | ORAI1 (0.73) | ORAI1STIM1ABL1KCNH2MAP4K4 | |
| SCHEMBL1822638 | 0.81 | STIM1 (0.67) | ORAI1STIM1ABL1MEN1KMT2A | |
| SCHEMBL16456537 | 0.81 | ORAI1 (0.67) | ORAI1STIM1ABL1LMNATYK2 | |
| SCHEMBL5550956 | 0.81 | ORAI1 (0.67) | ORAI1STIM1LMNATYK2JAK2 | |
| SCHEMBL16563988 | 0.80 | ORAI1 (0.66) | ORAI1STIM1LMNATYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250312336-A1 | Compositions And Methods For Treating Cancer With Calcium Channel Inhibitors | INSTITUTE FOR CANCER RES D/B/A THE RES INSTITUTE OF FOX CHASE CANCER CENTER (US) | 2025-10-09 | — | — | US | claimed |
| US-20230414609-A1 | USES OF ORAI1-SPECIFIC CALCIUM CHANNELS IN TREATMENT OF ORAL CANCER | NEW YORK UNIVERSITY | 2023-12-28 | — | — | US | claimed |
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | CALCIMEDICA, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| US-20250312336-A1 | Compositions And Methods For Treating Cancer With Calcium Channel Inhibitors | INSTITUTE FOR CANCER RES D/B/A THE RES INSTITUTE OF FOX CHASE CANCER CENTER (US) | 2025-10-09 | — | — | US | disclosed |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | AVENUE CAPITAL MANAGEMENT II, L.P. | 2025-04-17 | — | — | US | disclosed |
| CN-116194439-B | SOCE inhibitors and therapeutic uses thereof | 国家医疗保健研究所 | 2025-04-08 | — | — | CN | disclosed |
| US-20250073202-A1 | METHODS TO TREAT RENAL DISORDERS USING CALCIUM CHANNEL INHIBITORS | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2025-03-06 | — | — | US | disclosed |
| CN-119548498-A | Medicine for treating coronary calcification or myocardial ischemia or infarction | 澳门科技大学 | 2025-03-04 | — | — | CN | disclosed |
| EP-4465988-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | Calcimedica, Inc. (US) | 2024-11-27 | — | — | EP | disclosed |
| CN-118871110-A | Methods and compositions for treating inflammatory lesions of the lung | 钙医学公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118806904-A | Medicine for treating coronary calcification | 澳门科技大学 | 2024-10-22 | — | — | CN | disclosed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | disclosed |
| WO-2023141523-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | CALCIMEDICA, INC. (US) | 2023-07-27 | — | — | WO | disclosed |
| CN-116194439-A | SOCE inhibitors and therapeutic uses thereof | 国家医疗保健研究所 | 2023-05-30 | — | — | CN | disclosed |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | AVENUE CAPITAL MANAGEMENT II, L.P. | 2023-04-20 | — | — | US | disclosed |
| CN-115835878-A | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | 钙医学公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4106871-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" (IT) | 2022-12-28 | — | — | EP | disclosed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | disclosed |
| EP-4041216-A1 | ANTIVIRAL COMPOUNDS AND METHODS | The University of Nottingham (GB) | 2022-08-17 | — | — | EP | disclosed |
| CN-107847548-B | Substance P, mast cell degranulation inhibitor and peripheral neuropathy | 贝思以色列女会吏医学中心公司 | 2022-06-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | ORAI1, SARAF, STIM1 | ORAI1 1/4885STIM1 3/4885ABL1 2890/4885 |
| US-12544371-B2 | Methods and compositions for treating acute lung injury and acute respiratory distress syndrome | ORAI1, MAVS, CASR | ORAI1 1/4885STIM1 231/4885ABL1 1205/4885 |
| US-20250120969-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION INJURY IN THE LUNGS | IL1B, MAVS, MMP8 | ORAI1 92/4885STIM1 852/4885ABL1 2252/4885 |
| US-20230120819-A1 | METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME | MAVS, ATF1, IL1B | ORAI1 68/4885STIM1 943/4885ABL1 2160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.