Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563837 | 0.80 | ALDH1A1 (0.39) | HTTKDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL16563942 | 0.79 | KDM4E (0.40) | HTTKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL16564132 | 0.78 | KMT2A (0.44) | HTTKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL16564136 | 0.76 | ALOX15 (0.43) | LMNATSHRMAPTALOX15 | |
| SCHEMBL16563648 | 0.75 | MAPT (0.52) | ENPP2POLBMAPTNPSR1RAB9A | |
| SCHEMBL16563773 | 0.73 | MAPT (0.43) | ENPP2MAPTRAB9ANTRK1 | |
| SCHEMBL16563611 | 0.72 | POLB (0.42) | KDM4EGAAKMT2ANPC1LMNA | |
| SCHEMBL16564046 | 0.72 | P2RX7 (0.47) | KMT2AMEN1NPC1LMNAATM | |
| SCHEMBL16563847 | 0.71 | MEN1 (0.47) | KMT2AMEN1NPC1POLBMAPT | |
| SCHEMBL16563497 | 0.71 | PTGES (0.39) | HTTGAAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |