Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563942 | 0.83 | KDM4E (0.40) | ALDH1A1KDM4ENPSR1KMT2AMEN1 | |
| SCHEMBL16563648 | 0.81 | MAPT (0.52) | NPSR1MAPTRAB9A | |
| SCHEMBL16563570 | 0.80 | HTT (0.40) | KDM4ENPSR1KMT2AMEN1MAPT | |
| SCHEMBL16564132 | 0.80 | KMT2A (0.44) | ALDH1A1KDM4ENPSR1KMT2AMEN1 | |
| SCHEMBL16564136 | 0.78 | ALOX15 (0.43) | MAPTALOX15LMNATSHRROCK1 | |
| SCHEMBL16563773 | 0.77 | MAPT (0.43) | MAPTRAB9A | |
| SCHEMBL16563611 | 0.76 | POLB (0.42) | ALDH1A1KDM4EKMT2ANPC1RAB9A | |
| SCHEMBL16564046 | 0.74 | P2RX7 (0.47) | ALDH1A1KMT2AMEN1ALOX15NPC1 | |
| SCHEMBL16563605 | 0.74 | MEN1 (0.45) | ALDH1A1NPSR1KMT2AMEN1HTT | |
| SCHEMBL16563847 | 0.73 | MEN1 (0.47) | KMT2AMEN1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |