Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 | P05023 | 6/20 | 1.00 |
| ▸ | ATP1B1 | P05026 | 6/20 | 1.00 |
| ▸ | ATP1A3 | P13637 | 6/20 | 1.00 |
| ▸ | ATP1B2 | P14415 | 6/20 | 1.00 |
| ▸ | ATP1A2 | P50993 | 6/20 | 1.00 |
| ▸ | ATP1B3 | P54709 | 6/20 | 1.00 |
| ▸ | FXYD2 | P54710 | 6/20 | 1.00 |
| ▸ | ATP1A4 | Q13733 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | ZFP91 | Q96JP5 | 1/20 | 1.00 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.63 |
| ▸ | ATP12A | P54707 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bufalin SCHEMBL12756993 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL16628184 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL19415190 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL14477877 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL20127236 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL23382204 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL15864888 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL21083171 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL21129737 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Bufalin SCHEMBL8257006 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1997 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121270638-B | Method for extracting bufadienolide from bufadienolide medicinal material and application | 亳州学院 | 2026-05-15 | — | — | CN | claimed |
| CN-122005693-A | Application of Jiaweidanzhi Xiaoyao powder or extract thereof in preparation of medicines for treating depression complicated with ulcerative colitis | 河南中医药大学 | 2026-05-12 | — | — | CN | claimed |
| WO-2026086871-A1 | ANTI-AGEING COMPOUNDS, USES THEREFOR, METHOD FOR IDENTIFYING, AND COMPOSITIONS CONTAINING | Centre for Translational Stem Cell Biology Limited (CN) | 2026-04-30 | — | — | WO | claimed |
| US-20250381202-A1 | PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY | ZOUNEK ALEX (DE) | 2025-12-18 | — | — | US | claimed |
| US-20250222024-A1 | METHOD AND COMPOSITION FOR TREATING CORONA VIRUS, INFLUENZA, AND ACUTE RESPIRATORY DISTRESS SYNDROME | REVERSPAH LLC (US) | 2025-07-10 | — | — | US | claimed |
| US-20250205258-A1 | DERIVATIVES OF BUFALIN AND THEIR PREPARATION METHODS, AS WELL AS COMPOSITIONS, PREPARATIONS, AND APPLICATIONS | SHANGHAI MEWSGEN BIOTECHNOLOGY CO LTD (CN) | 2025-06-26 | — | — | US | claimed |
| CN-120019812-A | Artificial toad venom composition and application thereof | 南京中医药大学 | 2025-05-20 | — | — | CN | claimed |
| EP-4551565-A1 | PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY | Zounek, Alex (DE) | 2025-05-14 | — | — | EP | claimed |
| CN-119909196-A | Composition for inhibiting tumor, nano-drug, preparation method and application | 湖南新汇制药股份有限公司 | 2025-05-02 | — | — | CN | claimed |
| WO-2025086855-A1 | AZIDE PRODRUG COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 中科帅天医药(深圳)有限公司 | 2025-05-01 | — | — | WO | claimed |
| WO-2002014343-A1 | BUFADIENOLIDE DERIVATIVES AND USE AS IMMUNOSUPPRESSIVE, ANTIINFLAMMATORY AND ANALGESIC AGENTS | TERNESS, PETER (DE) | 2002-02-21 | — | — | WO | claimed |
| EP-1150687-A2 | METHODS FOR ANTI-TUMOR THERAPY | Cellpath, Inc. (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2000047215-A2 | METHODS FOR ANTI-TUMOR THERAPY | CELLPATH, INC. (US) | 2000-08-17 | — | — | WO | claimed |
| EP-0988373-A1 | SELECTION MARKER | Karolinska Innovations AB (SE) | 2000-03-29 | — | — | EP | claimed |
| US-6037326-A | APPLYING TO THE SKIN AN INHIBITOR OF A DNA TOPOISOMERASE | GILLETTE COMPANY, THE | 2000-03-14 | — | — | US | claimed |
| WO-2000010552-A2 | USE OF ANTI-ANGIOGENIC AGENTS FOR INHIBITING VESSEL WALL INJURY | GLOBAL VASCULAR CONCEPTS, INC. (US) | 2000-03-02 | — | — | WO | claimed |
| EP-0957891-A1 | REDUCTION OF HAIR GROWTH | HANDELMAN, Joseph H. (US) | 1999-11-24 | — | — | EP | claimed |
| WO-1998055603-A1 | NEW SELECTION MARKER | KAROLINSKA INNOVATIONS AB (SE) | 1998-12-10 | — | — | WO | claimed |
| WO-1998029086-A1 | REDUCTION OF HAIR GROWTH | HANDELMAN, JOSEPH, H. (US) | 1998-07-09 | — | — | WO | claimed |
| CN-1072183-A | Extract the method for bufalin and the purposes of bufalin and relevant derivative thereof | ZHANG LISHA (CN) | 1993-05-19 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250381202-A1 | PRODRUG KIT FOR MULTI-PRONGED CHEMOTHERAPY | KIT, CTSL, PAICS | ATP1A1 3241/4885ATP1B1 3180/4885ATP1A3 4201/4885 |
| US-20250222024-A1 | METHOD AND COMPOSITION FOR TREATING CORONA VIRUS, INFLUENZA, AND ACUTE RESPIRATORY DISTRESS SYNDROME | NFKBIA, ALOX15, ALOX15B | ATP1A1 867/4885ATP1B1 1538/4885ATP1A3 1454/4885 |
| US-20250205258-A1 | DERIVATIVES OF BUFALIN AND THEIR PREPARATION METHODS, AS WELL AS COMPOSITIONS, PREPARATIONS, AND APPLICATIONS | KCNN1, KCNN2, KCNJ1 | ATP1A1 67/4885ATP1B1 115/4885ATP1A3 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.