Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571392 | 0.87 | PTPN11 (0.42) | NUDT1PTPN11SYKALOX15CCNC | |
| SCHEMBL16571390 | 0.87 | CCNC (0.47) | NUDT1SYKGRM5CCNCCDK8 | |
| SCHEMBL16571097 | 0.85 | CCNC (0.46) | NUDT1PTPN11SYKALOX15CCNC | |
| SCHEMBL16571420 | 0.83 | ALOX15 (0.49) | NUDT1PTPN11SYKALOX15XDH | |
| SCHEMBL16571406 | 0.81 | PDE4A (0.41) | NUDT1SYKALOX15XDHSLC22A12 | |
| SCHEMBL19478398 | 0.80 | XDH (0.39) | PTPN11SYKALOX15XDHSLC22A12 | |
| SCHEMBL16571121 | 0.79 | XDH (0.39) | NUDT1PTPN11ALOX15XDHSLC22A12 | |
| SCHEMBL16571417 | 0.79 | XDH (0.38) | PTPN11ALOX15XDHSLC22A12 | |
| SCHEMBL16571158 | 0.78 | ALOX15 (0.49) | NUDT1SYKALOX15 | |
| SCHEMBL16571634 | 0.78 | SLC22A12 (0.38) | PTPN11SYKALOX15XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | claimed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | claimed |
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |